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ab initio quantum mechanical studies of a pH dependant G:G conformational switchAuthors: Purshotam Sharma,Sitansh Sharma,Harjinder Singh,Abhijit Mitra,Dhananjay Bhattacharyya Conference: Bioconvene 2007, International conference on Bioinformatics and Drug Discovery, December 20-22, 2007 : University of Hyderabad, Hyderabad, India. Date: 2008-06-05 Report no: IIIT/TR/2008/7 AbstractIdentification of base pairs which can participate, through multimodality of edge interactions, in conformational switching events, and evaluation of possible environmental factors responsible for the switching can lead to greater understanding of RNA functional dynamics. Moleculardynamics studies by Schneider et al involving multimodality in C:U W:W cis interactions in aqueous medium, arguments forwarded by Van Dongen et al in support of a pH dependent G:C W:W cis to G:C H:W cis conformational switch and the postulation of putative role of a minor motifs in ribosomal dynamics through structure analysis, are examples of efforts in this section. Here we discuss the computational analysis of a putative pH dependant conformational switching of G:G base pairs in RNA structures. Full paper: pdf Centre for Computational Natural Sciences and Bioinformatics |
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