IIIT Hyderabad Publications |
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Can’t Get Enough: The Puzzle of Addiction and the BrainAuthor: Arun Garimella Date: 2021-03-06 Report no: IIIT/TH/2021/40 Advisor:Vinoo Alluri AbstractIn this thesis, I investigate the effects of certain psychoactive substances on the brain and propose a novel method to deal with addiction. The first section deals with the effect of marijuana on the different hippocampus subfields. The hippocampus has the highest concentration of cannabinoid receptors, the primary binding site for THC, the primary pscyhoactive constituent of marijuana. But this concentration varies across the subfields. We also check for the effects of varied consumption in this study by splitting the cannabis consuming group into two subgroups: heavy consumers and light consumers. The next section deals with a method to administer transcranial magnetic stimulation in patients with addiction and depression disorders amongst others. We focus on using a personalised locus rather than a population driven locus. The main issue faced is the highly variable nature of the dorsolateral prefrontal cortex, the target site for the administration. Subsequently, we highlight the importance of preprocessing and quality control in the processing of magnetic resonance images in both humans and non-human primates. Existing approaches in this area fail to deal with multiple artifacts often encountered while working on these scans. We then use quality control to develop a novel pipeline to preprocess macaque structural images. We also use quality control in the development of a state of the art pipeline for preprocessing and processing human diffusion weighted tensor images. Full thesis: pdf Centre for Cognitive Science |
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